![]() The spindle continues to elongate during telophase, as the chromosomes arriving at the poles are released from the spindle microtubules and the nuclear envelope re-forms around them.īoth the assembly and the function of the mitotic spindle depend on microtubule-dependent motor proteins. At anaphase, the sister chromatids abruptly separate and are drawn to opposite poles of the spindle at about the same time, the spindle elongates, increasing the separation between the poles. When the nuclear envelope breaks down at prometaphase, the microtubules of the spindle are able to capture the chromosomes, which eventually become aligned at the spindle equator, forming the metaphase plate (see Panel 18-1). It is constructed from microtubules and their associated proteins, which both pull the daughter chromosomes toward the poles of the spindle and move the poles apart.Īs we have seen, the spindle starts to form outside the nucleus while the chromosomes are condensing during prophase. ![]() The segregation of the replicated chromosomes is brought about by a complex cytoskeletal machine with many moving parts-the mitotic spindle. ![]()
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